Red Mesa High School offer classes such as:
Math Department: Algebra 1 & 2, Geometry, Trigonometry, and Pre-Calculus.
Science Department: Earth Science, Intro to Science, Physical Science, General Biology, and Advanced Biology.
English Department: English 9, English 10, English 11, English 12, Shakespeare, Native American Literature, Exploring Literature, AIMS Reading/Writing Prep, Modern Literature, Comp/Creative Writing.
Social Studies Department: American History, Southwest Studies, World History/Geography, Navajo Government, and US Government and Economics.
Culture Department: Navajo Language 1 and Navajo Language 2.
Health Department: Health and Physical Education.